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. 2021 Jul 2;14:176. doi: 10.1186/s12920-021-01022-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Go and Reactome enrichment pathway analysis of up- and down-regulated DEGs. A Dot plot shows GO terms of Biological Process identified by Panther GO-slim analysis. B Dot plot shows GO terms of Cellular Component identified by Panther GO-slim analysis. C Dot plot shows significantly enriched GO terms based on molecular function (FDR < 0.05) of up-regulated DEGs identified by Panther GO complete analysis. D Dot plot shows top 20 enriched Reactome pathways. The size of the dot is based on gene count enriched in the pathway, and the color of the dot shows the pathway enrichment significance