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. 2021 Jul 1;12:49. doi: 10.1186/s13229-021-00454-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Reported findings in the context of cortico-striatal loop circuits. Baseline differences and group (ASD > neurotypicals) by drug (CBCV > PLC) interaction effects on cortico-striatal loop circuits, including the limbic and associative/cognitive loop, each of which are theorized to include different GPi/SNR and thalamic regions. Grey arrows indicate functional connections. ASD autism spectrum disorder, CBDV cannabidivarin, FC functional connectivity, GPi globus pallidus pars interna, L left, MD mediodorsal nucleus, PF parafascicular nucleus of the thalamus (dl: dorsolateral extension), R right, SNr substantia nigra pars reticulate, VA ventral anterior nucleus of the thalamus (mc: magnocellular part; pc: parvocellular part), VL ventrolateral nucleus of the thalamus (c: caudal part; m: medial part), vrP ventral-rostral putamen, VSi inferior ventral striatum. *The anterior paracentral lobule is associated with sensori-motor processing and may represent ectopic FC within the ‘limbic loop’ here