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Effects of specific inhibitor of CYP3A and CYP2D6 on CLint of THY1773 in human liver microsomes and estimated fraction metabolized
| CYP isoforms | Selective inhibitor (concentration) | CLint (μl/min/mg) | fm |
|---|---|---|---|
| – | None | 11.2 ± 0.898 | N.A. |
| CYP3A | Ketoconazole (1 μmol/L) | 0.961 a | 0.914 |
| CYP2D6 | Quinidine (1 μmol/L) | 10.2 ± 0.509 | 0.0893 |
Values are presented as the mean ± SD of triplicate determinations.
N.A., not applicable.
Value is presented as the mean of duplicate determinations.
