. 2021 Apr 3;42(5):204–217. doi: 10.1002/bdd.2273

TABLE 5.

Predicted and observed human CL_total of THY1773 and fold error

Prediction method	Predicted human CL_total (ml/h/kg)	Observed human CL_total/F (ml/h/kg)	Fold error ^a
FCIM	64.1	17.2	3.7
Two species allometry	224		13
IVIVE method without ESF	15.0		0.87
IVIVE method with ESF	63.4		3.7

ESF, empirical scaling factor; FCIM, fraction corrected intercept method; IVIVE, in vitro–in vivo extrapolation.

^{^a}

Fold error was calculated by dividing predicted CL_total by observed oral CL_total (CL_total/F) assuming bioavailability (F) was 100%.