Figure 3.

1 shows excellent bactericidal activity against S. aureus. Time‐dependent killing of early‐exponential (a) and late‐exponential phase‐grown (b) cells treated with 1 at 1× (open circles) and 2× MIC (circles), with teixobactin (diamonds) and vancomycin (triangles) both at 10× MIC. Cells left untreated are shown with squares. Data are representative of three independent experiments. c) 1‐induced lysis is mediated by the major autolysin AtlA in S. aureus. Deletion of atlA results in markedly reduced autolysis after treatment with 1 and TEIX.