FIGURE 4.
Modulation of M. leprae–infected INF‐γ−/− footpad induration and cellular composition by Clofazimine and rifampin. IFN‐γ−/− mice were infected in the hind footpads with 30 × 106 M. leprae. At 24 wk postinfection, mice were treated daily for 10 d with vehicle (sham), 1 mg/mL clofazimine (CLF), or 10 mg/kg rifampin (RMP). A, Footpad induration was measured with a vernier caliper. B, At 42 d, footpads cells were isolated and the number of macrophages (open bars) and neutrophils (hatched bars) were determined by flow cytometry. C, M. leprae viability was assessed by radiorespirometry