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PGC‐1α regulates fibrotic progression in monocyte‐derived macrophages. Lung injury promotes Akt1 activation and the generation of the mitochondrial ROS (mtROS), which induces p38 MAPK. The p38‐mediated increase of PGC‐1α activation occurs via Akt1 and augments the transcription of mitochondrial DNA genes, including TFAM and CS (citrate synthase) to induce apoptosis resistance in monocyte‐derived macrophages and fibrotic progression
