Figure 1.

Involvement of GPCRs and G proteins in human diseases and drug development. A) Distribution of approved drugs (small molecules and biologics) per human protein family class derived from Santos et al. ^[15] B) Putative primary Gα protein coupling, based on the classification of GPCR signaling according to Sriram et al. ^[5] C) Involvement of Gαi/s subfamilies in multiple disorders such as cancer, heart failure, endocrine disorders or thrombosis, adapted from Li et al. ^[1]