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Natural compounds targeting the Gα‐GPCR interface. A) Modification of Gαi by pertussis toxin (PTX) derived from Mangmool et al. [129] PTX transfers the ADP‐ribose element from nicotinamide adenine dinucleotide (NAD+) to Gαi CysG.H5.23. B) Crystal structure of PTX (gray, PDB ID: 1PRT [128] ). The S1 subunit (magenta) is important for Gαi inhibition. C) G protein‐bound NMR structure ensemble (14 structures) of mastoparan‐X (H‐INWKGIAAMAKKLL‐NH2, PDB ID: 1 A13 [133] ).
