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. 2021 Mar 22;16(11):1697–1716. doi: 10.1002/cmdc.202100039

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© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Chemical structures of mRNA display‐derived peptides targeting the Gα accessory protein interface. The peptides cycGiBP (10), ^[233] cycPRP‐1 (11), cycPRP‐3 (12), ^[234] and Gα SUPR (13) ^[235] are Gαi1⋅GDP selective. GsNI‐1 (14) ^[217] is Gαs⋅GTP selective.