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. 2021 Mar 15;193(3):637–658. doi: 10.1111/bjh.17361

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© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig 2 — Transfusion‐dependent patients with haemolytic diseases are hallmarked by elevated transferrin (Tf) saturation and non‐Tf‐bound iron (NTBI) formation. (A–C) Measurement of iron, Tf saturation and NTBI in sera of healthy subjects (Ctrl), as well as patients with β‐thalassaemia (β‐thal) intermedia (int) and major. (D) Correlation between NTBI and Tf saturation includes data from Ctrls and patients with β‐thal. (E–G) Measurement of iron, Tf saturation and NTBI in sera of Ctrls, as well as patients with sickle cell disease (SCD1 and 2) and spherocytosis (SPH). A few samples of patients with β‐thal major were included for comparison. (H) Correlation between NTBI and Tf saturation includes data from Ctrls and patients with SCD (SCD 1 and 2). Values represent mean ± SD. *P < 0·05; **P < 0·01; ***P < 0·001; ****P < 0·0001.