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. 2021 Mar 15;193(3):637–658. doi: 10.1111/bjh.17361

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© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig 3 — Iron overload in transfusion‐dependent patients with haemolytic diseases is associated with inappropriate hepcidin levels. (A–D) Measurement of haemoglobin, erythropoietin (EPO), hepcidin and hepcidin–serum ferritin (Ft) ratio in blood samples and sera of healthy subjects (Ctrl), and patients with β‐thalassaemia (β‐thal) intermedia (int) and major; (E–H) Measurement of haemoglobin, EPO, hepcidin and hepcidin–Ft ratio in sera of Ctrls, as well as patients with sickle cell disease (SCD 1 and 2) and spherocytosis (SPH). EPO is shown only in the SPH an SCD 1 groups. Values represent mean ± SD. *P < 0·05; ***P < 0·001; ****P < 0·0001.