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. 2021 Mar 15;193(3):637–658. doi: 10.1111/bjh.17361

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© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig 6 — Transfusion‐dependent patients with haemolytic diseases are hallmarked by elevated circulating inflammatory cytokines. (A) Measurement of tumour necrosis factor α (TNFα), interleukin 6 (IL‐6), IL‐1β and vascular endothelial growth factor (VEGF) in sera of healthy subjects (Ctrls), as well as patients with β‐thalassaemia (β‐thal) intermedia (int) and major. (B, C) Significant correlations of IL‐6 and VEGF with haem/iron‐related parameters including data from Ctrls and patients with β‐thal major are shown. (D) Measurement of TNFα, IL‐6 and VEGF in sera of Ctrls, as well as patients with sickle cell disease (SCD 1 and 2), and spherocytosis (SPH). (E, F) Significant correlations of TNFα and IL‐6 with haem/iron‐related parameters including data from Ctrls and patients with SCD 1 and 2 or SPH are shown. Values represent mean ± SD. *P < 0·05; **P < 0·01; ***P < 0·001; ****P < 0·0001.