TABLE 1.
Participants' demographics and CSF and PET measures
| N = 318 | Mean (SD) |
|---|---|
| Demographics | |
| Age (years) [range] | 61.4 (4.6) [50.4 to 74.3] |
| Women, n(%) | 199 (62.6) |
| Education (years) | 13.4 (3.5) |
| APOE‐ε4 carriers, n(%) | 168 (52.8) |
| Time difference LP ‐ PET (days) | 96.7 (67.4) |
| MMSE | 29.2 (1.0) |
| FCSRT ‐ Delayed free recall | 11.6 (2.1) |
| CSF measures | |
| Aβ1‐42 (pg/mL) [range] | 1328 (569) [307 to 3595] |
| Aβ1‐40 (ng/mL) | 17.6 (5.0) |
| p‐tau (pg/mL) | 16.1 (6.3) |
| t‐tau (pg/mL) | 198 (68) |
| NfL (pg/mL) | 81.5 (26.8) |
| Neurogranin (pg/mL) | 805 (323) |
| GFAP (ng/mL) | 7.5 (2.3) |
| YKL‐40 (ng/mL) | 148 (53) |
| sTREM2 (ng/mL) | 7.9 (2.3) |
| S100b (ng/mL) | 1.01 (0.22) |
| IL‐6 (pg/mL) | 3.8 (1.4) |
| α‐synuclein (pg/mL) | 199 (81) |
| PET measures | |
| Centiloids [range] | 2.7 (16.6) [−23.9, 81.6] |
Mean (SD) values are shown unless otherwise stated.
Aβ, amyloid‐β; FCSRT, Free and Cued Selective Reminding Test; GFAP, glial fibrillary acidic protein; IL‐6, interleukin 6; LP, lumbar puncture; MMSE, Mini‐Mental State Examination; NfL, neurofilament light; p‐tau, phosphorylated tau; SD, standard deviation; sTREM2, soluble triggering receptor on myeloid cells 2 (TREM2); t‐tau; total tau.