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. 2021 Mar 15;254(4):494–504. doi: 10.1002/path.5639

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© 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Loss of TRIM28 protein expression in TRIM28‐mutated Wilms' tumour. Top: immunohistochemical staining with anti‐KAP1 antibody (ab10484) in an epithelial Wilms' tumour (WT) of a 7‐month‐old boy with a somatic TRIM28 mutation showing absent nuclear staining in tumour cells, with retained expression of KAP1 in non‐tumoural cells. Bottom: retained expression of KAP1 in adjacent normal kidney tissue. The counterstaining with Mayer's haematoxylin (blue) appears more intense in the tumour, due to the fact that the tumour slice is slightly thicker and lacks KAP1 (brown) staining.