TABLE 3.
Algorithm validation in external cohorts
| Cohort details | EMRPC a | EDI b | POND c |
|---|---|---|---|
| Total N | 80,237 | 103,948 | 661 |
| Number with ASD | 1062 | 1503 | 415 |
| Estimated ASD Prevalence (%) | 1.3 | 1.4 | N/A d |
| Age range | 1–24 years | 5–6 years | 1–21 years |
| Performance of selected algorithm | |||
| Sensitivity (%) | 51.8 | 55.9 | 72.8 |
| Specificity (%) | 99.7 | 99.6 | 94.3 |
| PPV (%) | 62.5 | 70.1 | 95.6 |
| NPV (%) | 99.4 | 99.4 | 67.2 |
Abbreviations: ASD, autism spectrum disorder; EDI: early development instrument; EMRPC: electronic medical record primary care; NPV, negative predictive value; POND: province of Ontario neurodevelopmental disorders; PPV, positive predictive value.
EMRPC data, housed at ICES. Individuals with ASD were identified using an EMR‐based case‐finding algorithm.
EDI is a teacher‐completed measure of early development outcomes of children in kindergarten. Data is from a cohort of 5–6‐year‐old children in Ontario in 2015.
POND Study is an ongoing cross‐sectional study of children and youth with neurodevelopmental disorders.
Prevalence of ASD is not estimated in POND as it is a cohort of children and youth with neurodevelopmental disorders.