TABLE 2.

Potential signs and symptoms at presentation observed in MMA and PA patients

Acute presentation	Chronic presentation
Nervous system
Acute encephalopathy	Hypotonia
Seizures	Developmental delay
Movement disorders (more frequent in PA)	Seizures
Stroke‐like episodes (more frequent in MMA)	Movement disorders/dystonia
Gastrointestinal system
Vomiting	Recurrent vomiting with ketoacidosis
Feeding difficulties	Failure to thrive
	Pancreatitis
Haematopoietic system
Neutropenia, pancytopenia	Neutropenia, pancytopenia
Heart (mostly in PA)
Acute cardiac failure (mostly based on cardiomyopathy)	Cardiomyopathy
Arrhythmias	Prolonged QTc in ECG
Kidney
	Chronic renal failure (almost exclusively in MMA)

Abbreviations: ECG, electrocardiogram; MMA, methylmalonic acidaemia; PA, propionic acidaemia; QTc, corrected QT interval.