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. 2021 Mar 19;152(Suppl 1):3–57. doi: 10.1002/ijgo.13522
1. Executive summary 7
2. Target audience 11
3. Assessment of quality of evidence and grading of strength of recommendations 12
4. Fetal growth restriction: background, definition, etiology, and risks 13
4.1. Background 13
4.2. Terminology and definitions 13
4.2.1. Consensus‐based definition of placenta‐related fetal growth restriction 13
4.2.2. Early‐ versus late‐onset fetal growth restriction 13
4.3. Etiology of fetal growth restriction 16
4.4. Risks associated with fetal growth restriction 16
4.5. Recommendations 17
5. Early prediction and prevention of fetal growth restriction 18
5.1. History‐based risk factors 18
5.2. Biochemical markers 18
5.3. Ultrasound markers 19
5.4. Prediction models 19
5.5. Prevention of fetal growth restriction in high‐risk populations 20
5.5.1. Lifestyle modifications 20
5.5.2. Medical interventions 20
5.6. Recommendations 21
6. Detection of fetal growth restriction 22
6.1. Symphysis–fundal height 22
6.2. Sonographic fetal weight estimation 22
6.3. Is there a role for routine third‐trimester ultrasound to assess fetal growth? 22
6.4. Which growth chart should be used to determine fetal weight percentile? 23
6.4.1. Growth references versus growth standards 23
6.4.2. Charts based on birth weight versus sonographic fetal weight estimation 23
6.4.3. Universal versus customized charts 24
6.4.4. Description of commonly available charts 24
6.4.5. How to choose the best chart 25
6.5. How to assess fetal growth in twin gestations 26
6.6. Recommendations 27
7. What kind of investigations should be performed when fetal growth restriction is suspected? 28
7.1. Detailed history 28
7.2. Detailed anatomy scan 28
7.3. Doppler studies 28
7.4. Additional testing 28
7.5. Recommendations 29
8. Management of pregnancies with fetal growth restriction 30
8.1. Monitoring 30
8.1.1. Fetal movement counting 30
8.1.2. Fetal heart rate monitoring 30
8.1.3. Computerized fetal heart rate monitoring 32
8.1.4. Ultrasound measurement of amniotic fluid volume 33
8.1.5. Biophysical profile scoring 33
8.1.6. Umbilical artery Doppler 33
8.1.7. Cerebral artery Doppler 33
8.1.8. Ductus venosus Doppler 34
8.1.9. Surveillance strategy 34
8.2. Timing of delivery 35
8.2.1. Gestational age‐related risks in fetal growth restriction 35
8.2.2. Gestational age‐related management strategy 35
8.2.3. Absolute delivery criteria for fetal growth restriction (independent of gestational age) 35
8.2.4. Relative delivery criteria for fetal growth restriction (adjusted for gestational age) 36
8.3. Mode of delivery and intrapartum considerations 36
8.4. Medical interventions 37
8.4.1. Antenatal corticosteroids 37
8.4.2. Magnesium sulfate for neuroprotection 37
8.4.3. Treatments under investigation 37
8.5. Recommendations 38
9. Postpartum assessment and counselling for future pregnancies 40
9.1. Infant follow‐up 40
9.2. Maternal follow‐up 40
9.3. Counselling regarding future pregnancies 40
9.3.1. Risk of recurrence based on severity and onset 40
9.3.2. Risk of recurrence based on placental histopathology 41
9.3.3. Role of thrombophilia screening 41
9.3.4. Preconception counselling and management of future pregnancies 41
9.4. Recommendations 43
10. Summary and future research directions 44
11. References 45