1. Executive summary |
7 |
2. Target audience |
11 |
3. Assessment of quality of evidence and grading of strength of recommendations |
12 |
4. Fetal growth restriction: background, definition, etiology, and risks |
13 |
4.1. Background |
13 |
4.2. Terminology and definitions |
13 |
4.2.1. Consensus‐based definition of placenta‐related fetal growth restriction |
13 |
4.2.2. Early‐ versus late‐onset fetal growth restriction |
13 |
4.3. Etiology of fetal growth restriction |
16 |
4.4. Risks associated with fetal growth restriction |
16 |
4.5. Recommendations |
17 |
5. Early prediction and prevention of fetal growth restriction |
18 |
5.1. History‐based risk factors |
18 |
5.2. Biochemical markers |
18 |
5.3. Ultrasound markers |
19 |
5.4. Prediction models |
19 |
5.5. Prevention of fetal growth restriction in high‐risk populations |
20 |
5.5.1. Lifestyle modifications |
20 |
5.5.2. Medical interventions |
20 |
5.6. Recommendations |
21 |
6. Detection of fetal growth restriction |
22 |
6.1. Symphysis–fundal height |
22 |
6.2. Sonographic fetal weight estimation |
22 |
6.3. Is there a role for routine third‐trimester ultrasound to assess fetal growth? |
22 |
6.4. Which growth chart should be used to determine fetal weight percentile? |
23 |
6.4.1. Growth references versus growth standards |
23 |
6.4.2. Charts based on birth weight versus sonographic fetal weight estimation |
23 |
6.4.3. Universal versus customized charts |
24 |
6.4.4. Description of commonly available charts |
24 |
6.4.5. How to choose the best chart |
25 |
6.5. How to assess fetal growth in twin gestations |
26 |
6.6. Recommendations |
27 |
7. What kind of investigations should be performed when fetal growth restriction is suspected? |
28 |
7.1. Detailed history |
28 |
7.2. Detailed anatomy scan |
28 |
7.3. Doppler studies |
28 |
7.4. Additional testing |
28 |
7.5. Recommendations |
29 |
8. Management of pregnancies with fetal growth restriction |
30 |
8.1. Monitoring |
30 |
8.1.1. Fetal movement counting |
30 |
8.1.2. Fetal heart rate monitoring |
30 |
8.1.3. Computerized fetal heart rate monitoring |
32 |
8.1.4. Ultrasound measurement of amniotic fluid volume |
33 |
8.1.5. Biophysical profile scoring |
33 |
8.1.6. Umbilical artery Doppler |
33 |
8.1.7. Cerebral artery Doppler |
33 |
8.1.8. Ductus venosus Doppler |
34 |
8.1.9. Surveillance strategy |
34 |
8.2. Timing of delivery |
35 |
8.2.1. Gestational age‐related risks in fetal growth restriction |
35 |
8.2.2. Gestational age‐related management strategy |
35 |
8.2.3. Absolute delivery criteria for fetal growth restriction (independent of gestational age) |
35 |
8.2.4. Relative delivery criteria for fetal growth restriction (adjusted for gestational age) |
36 |
8.3. Mode of delivery and intrapartum considerations |
36 |
8.4. Medical interventions |
37 |
8.4.1. Antenatal corticosteroids |
37 |
8.4.2. Magnesium sulfate for neuroprotection |
37 |
8.4.3. Treatments under investigation |
37 |
8.5. Recommendations |
38 |
9. Postpartum assessment and counselling for future pregnancies |
40 |
9.1. Infant follow‐up |
40 |
9.2. Maternal follow‐up |
40 |
9.3. Counselling regarding future pregnancies |
40 |
9.3.1. Risk of recurrence based on severity and onset |
40 |
9.3.2. Risk of recurrence based on placental histopathology |
41 |
9.3.3. Role of thrombophilia screening |
41 |
9.3.4. Preconception counselling and management of future pregnancies |
41 |
9.4. Recommendations |
43 |
10. Summary and future research directions |
44 |
11. References |
45 |