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. 2021 May 19;254(4):374–383. doi: 10.1002/path.5681

Table 1.

Cut‐off values of PD‐L1 IHC assays associated with PD‐1 and PD‐L1 checkpoint agents for treatment of NSCLC.

DAKO 28‐8 DAKO 22C3 VENTANA SP142 VENTANA SP263
PD‐L1 IHC assay cut‐off values

TC ≥ 1%

TC ≥ 5%

TC ≥ 10%

TPS ≥ 1%

TPS ≥ 50%

TC ≥ 1% or IC ≥ 1%

TC ≥ 5% or IC ≥ 5%

TC ≥ 50% or IC ≥ 10%

TC ≥ 1%

TC ≥ 5%

TC ≥ 10%

TC ≥ 25%

TC ≥ 50%

IC, immune cell; TC, tumour cell; TPS, tumour proportion score.