TABLE 4.

High‐grade CIN lesions ranked according to immunoscore and FAM19A4/miR124‐2 methylation status with a potential management proposal based on the presumed progression risk to cervical cancer

Immunoscore group		IS 0‐2		IS 3‐4		IS 5‐6
MM status		MM−	MM+	MM−	MM+	MM−	MM+
CIN2	n	13	10	44	61	40	94
CIN3	n	2	5	19	27	28	154
<29 y	n	1	3	16	7	23	45
≥29 y	n	14	12	47	81	45	203
Total		15	15	63	88	68	248

Note: Yellow colour indicates low progression risk to cancer, follow‐up after 12 months. Orange colour indicates intermediate progression risk to cancer, follow‐up after 6 months. Red colour indicates high progression risk to cancer, LLETZ advised.

Abbreviations: CIN, cervical intraepithelial neoplasia; IS, immunoscore; MM, methylation marker; MM−, methylation marker negative; MM+, methylation marker positive; n, number of lesions.