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. 2021 Mar 3;254(4):344–357. doi: 10.1002/path.5632

Figure 3.

Figure 3

Schematic overview of the most described mechanisms involved in interactions between fibrotic stroma and macrophages. Hypothesised involvement of signalling pathways/molecules is illustrated with dashed frames. Upregulated pro‐inflammatory markers are depicted in blue, and profibrotic/anti‐inflammatory in red. Arg‐1, arginase‐1; FAK, focal adhesion kinase; TRPV4, transient receptor potential vanilloid type 4; YAP, Yes‐associated protein.