Figure 4.

Above: the aligned sequences of BmKTX ¹⁰¹ (1BKT), OSK1 ¹⁰² (1SCO), AnTx ¹⁰³ (KAX6C_ANUPH), moka1 ¹⁰⁴ (2KIR), and HsTx1 ¹⁰⁵ (1QUZ) are shown together with the pattern of their disulfide bridges. Residues in bold are amino acids of which mutations have been shown to alter K_v1.3 binding. Middle: Sequences of Tc32 ¹⁰⁶ (2JP6) and Pi1 ¹⁰⁷ (1WZ5) are shown. Below: Sequence of ShK ¹⁰⁸ (1ROO) is shown together with the pattern of its disulfide bridges. Residue in bold is an amino acid of which mutations have been shown to alter K_v1.3 binding [Color figure can be viewed at wileyonlinelibrary.com]