Figure 1.

Overview of the study strategy. A, Determination of genes that were consistently differentially expressed (DE) between preserved and lesional osteoarthritis (OA) subchondral bone in the overall data set. B, Determination of genes that were differentially expressed in knee subchondral bone. C, Determination of genes that were differentially expressed in hip subchondral bone. Number of genes represents the significantly differentially expressed genes (according to the false discovery rate method), excluding those that were differentially expressed only in hip samples. FC = fold change.