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. 2021 May 18:M21-0256. doi: 10.7326/M21-0256

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This article is made available via the PMC Open Access Subset for unrestricted re-use for research, analyses, and text and data mining through PubMed Central. Acknowledgement of the original source shall include a notice similar to the following: "© 2020 American College of Physicians. Some rights reserved. This work permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited." These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. The RBD IgG response by region. The figure displays overall adjusted median RBD index values, stratified by region. Adjusted medians were similar by region in July. Regions with higher antecedent burden of COVID-19 cases and death (Northeast and Midwest) had a slow, steady decline in index values. In the South and West, the peak occurred in August, indicating proportionally more recent infections in these regions. Median values account for age, sex, and residence in a majority-minority neighborhood, defined as a majority Hispanic, Black, or Hispanic and Black neighborhood. RBD = receptor-binding domain. * Plotted on log scale. — The figure displays overall adjusted median RBD index values, stratified by region. Adjusted medians were similar by region in July. Regions with higher antecedent burden of COVID-19 cases and death (Northeast and Midwest) had a slow, steady decline in index values. In the South and West, the peak occurred in August, indicating proportionally more recent infections in these regions. Median values account for age, sex, and residence in a majority-minority neighborhood, defined as a majority Hispanic, Black, or Hispanic and Black neighborhood. RBD = receptor-binding domain.

* Plotted on log scale.