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. 2021 Jun 18;12:690201. doi: 10.3389/fimmu.2021.690201

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Copyright © 2021 Ardighieri, Missale, Bugatti, Gatta, Pezzali, Monti, Gottardi, Zanotti, Bignotti, Ravaggi, Tognon, Odicino, Calza, Missolo-Koussou, Ries, Helft and Vermi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CSF1R and TREM-2 expression in OCs. Sections from HGSCs cases (A, B, E, F) and from cell-block preparations of polarized monocyte-derived Mϕ (C, D) immunostained as labeled. Magnification 200× (A, E; scale bar 100 um) and 400× (B, F, scale bar 50 um). CSF1R expression in OCs is largely restricted to TAMs (A). Double immunohistochemistry showing co-expression of pSTAT1Y701, IRF1 and CXCL10 in CSF1R⁺ TAMs (B). M1 type and M2 type Mϕ generated from peripheral blood monocytes express CSF1R (C). M1 type Mϕ generated from peripheral blood monocytes express TREM2 (D). TREM2 is expressed on TAMs in HGSCS. TREM2⁺ TAMs detected in ^HiOC-IS³⁰CD163^Hi (E); a fraction of TREM2⁺ TAMs co-expressed pSTAT1Y701, IRF1 and CXCL10 (F).