Fig. 6.

Cell compartment‐specific oncogenic functions of LINC00261. Inside the nucleus, LINC00261 functions as a transcriptional scaffold and recruits the SMAD2/3 transcriptional machinery to the FOXA2 cis‐regulatory elements, thereby increasing the FOXA2‐driven anchorage‐independent growth and metastatic gene programs. In the cytoplasm, LINC00261 sequesters the miR‐8485:RISC complex to block its binding with the CBX2 transcript, thereby increasing the CBX2‐driven proliferative gene program. Thus, LINC00261 orchestrates neuroendocrine trans‐differentiation in PCa by regulating CBX2 and FOXA2 activities via distinct, cellular compartment‐specific molecular mechanisms. RISC, RNA‐induced silencing complex.