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IL-4Rα–responsive B cells are essential in TH2 and IL-21 production. Representative flow cytometry plots showing lung CD4 T cells producing IL-4, IL-5, IL-13, and IL-21. Frequencies of CD4+cytokine+ cells are quantified on the right. This is part of Figs 2 and 3, D. Shown are means ± SDs from 1 representative experiment of 3 (n = 4-9). Significant differences between groups were analyzed by Student t test (Mann-Whitney) and are described as ∗P < .05, ∗∗P < .01.
