Table 3. Ocular tissue DFS concentration (μg/g of tissue) obtained from various topical formulations of DFS.
| Formulations (#) | Time (h) post instillation | Group # | Cornea | AH | IC | RC | Sclera |
|---|---|---|---|---|---|---|---|
| 0.1%w/v DFS solution (#1) | 4 | 1 | NA | 0.18 ± 0.06 | 0.93 ± 0.4 | NA | NA |
| 1.6%w/v DFSfree+DFS:IR(1:1)(3 + 1) suspension (#2) | 8 | 2 | 1.3 ± 1.0 | 0.18 ± 0.07 | 0.43 ± 0.19 | ND | 8.4 ± 1.7 |
| 20%w/w DFSfree Film (#3) | 4 | 3 | NA | 2.6 ± 0.2* | 2.7 ± 1.1b | NA | NA |
| 8 | 4 | 7.5 ± 3.4 | 0.7 ± 0.06b | 0.78 ± 0.35c | ND | 14.6 ± 4.8 | |
| 20%w/w DFSfree+DFS:IR(1:1)(3 + 1) Film (#4) | 4 | 5 | NA | 0.9 ± 0.2* | 1.02 ± 0.05 | NA | NA |
| 8 | 6 | 2.3 ± 1.4 | 0.36 ± 0.06a | 0.66 ± 0.15c | 0.09 ± 0.02 | 7.02 ± 4.03 |
AH - Aqueous humor, IC - Iris ciliary bodies, RC - Retina-choroid. NA - not analyzed, ND - below detection limit. Statistical significance was calculated using Tukey HSD (IBM SPSS 23). *Significantly different from all groups, aSignificantly different from group #5, bSignificantly different from all groups except group #5, cSignificantly different from group #3.