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. 2021 Jun 30;13(1):1938380. doi: 10.1080/19490976.2021.1938380

Figure 2.

Figure 2.

Butyrate stabilization of HIF in the presence of β-oxidation inhibition. (a) HIF-1α target mRNA expression in T84 cells treated with 10 mM butyrate with or without 1 mM MCPA, 1 mM DMOG, or 30 μM IOX2 for 4 h (n = 3, error bars: SEM, ns not significant, * p < .05, ** p < .01, *** p < .001, **** p < .0001 by 1-way ANOVA, Fisher’s multiple comparison). (b) HIF-1α protein expression in T84 cells treated with 10 mM butyrate with or without 1 mM MCPA for 4 h. (c) Quantified densitometry of HIF-1α protein expression in T84 cells treated with 10 mM butyrate with or without 1 mM MCPA for 4 h (n = 3, error bars: SEM, ns not significant, * p < .05, ** p < .01 by 1-way ANOVA, Fisher’s multiple comparison)