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. 2017 Feb 3;24(1):209–223. doi: 10.1080/10717544.2016.1245365

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Assessment of in vivo therapeutic efficacy of CUR-mPEG–PLA-Ch micelles compared to free CUR administered intraperitoneally in B16F10-tumor-bearing mice. (A and B). A graphical representation of measured tumor volume versus time postinjection, and the weight of the tumor isolated after sacrificing the animal post-treatment; (C) The body weight of mice of different treatment groups plotted against the duration of treatment (D) Apoptosis analysis. Apoptotic cells were detected in frozen tumor sections, determined by TUNEL assay and visualized by fluorescence microscopy. The left panel shows the sections stained with DAPI and the right panel shows the TUNEL staining. Magnifications −20 × objectives.