FIGURE 3.
Expression of receptor tyrosine kinases (RTK) ligand–receptor pairs and downstream pathway effectors in fetal gonads. (A) CellphoneDB analysis of RTK interactions between different clusters in male fetal gonads. Depicted are −log10 p-values (circle size) and log2 means (circle color) for the interacting pairs, for selected pairwise cluster combinations. (B) Violin plots of selected RTK ligands and receptors in male germ and somatic clusters. (C) CellphoneDB analysis of RTK interactions between different clusters in female fetal gonads. (D) Violin plots of selected RTK ligands and receptors in female germ and somatic clusters. (E) Heatmap showing the expression of genes of interest associated with RTK signaling pathway in male germ and somatic cell clusters. (F) A volcano plot showing RTK-related genes between PGC and GON clusters in male gonads. Table shows the top 15 differentially expressed genes. Genes in bold are common between male and female [see (H)]. (G) Heatmap showing the expression of genes of interest associated with RTK signaling pathway in female germ and somatic cell clusters. (H) A volcano plot showing RTK-related genes between PGC and GON clusters in female gonads. Table shows the top 15 differentially expressed genes.