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. 2021 Jun 18;9:661243. doi: 10.3389/fcell.2021.661243

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Copyright © 2021 Overeem, Chang, Spruit, Roelse and Chuva De Sousa Lopes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of NOTCH ligand–receptor pairs and downstream pathway effectors in fetal gonads. (A) CellphoneDB analysis of NOTCH interactions between different clusters in male fetal gonads. Circle size represents the −log₁₀ (p-value). Depicted are −log₁₀ p-values (circle size) and log₂ means (circle color) for the interacting pairs, for selected pairwise cluster combinations. (B)Violin plots of selected NOTCH receptors and ligands in male germ and somatic clusters. (C) CellphoneDB analysis of NOTCH interactions between different clusters in female fetal gonads. (D) Violin plots of selected NOTCH receptors and ligands in female germ- and somatic clusters. (E) Heatmap showing the expression of genes of interest associated with NOTCH signaling pathway in male germ and somatic cell clusters. (F) A volcano plot showing NOTCH-related genes between PGC and GON clusters in male gonads. Table shows the top 10 differentially expressed genes. Genes in bold are common between male and female, while genes in italics show divergent regulation. (G) Heatmap showing the expression of genes of interest associated with NOTCH signaling pathway in female germ and somatic cell clusters. (H) A volcano plot showing NOTCH-related genes between PGC and GON clusters in female gonads. Table shows the top seven differentially expressed genes.