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. 2021 Jun 18;12:696977. doi: 10.3389/fendo.2021.696977

Table 2.

Postprandial area under the curve values of biochemical parameters during the mixed-meal tolerance test.

Lean (n = 12) Centrally Obese (n = 12) P-value
WP PLA WP PLA Treatment Condition Treatment*Condition
Glucose AUC (mmol/L/min−1) a
0–60 min 3.8 ± 0.5 4.7 ± 0.7* 4.6 ± 0.4# 5.3 ± 0.6*# P <0.0001 P = 0.002 P = 0.468
0–240 min 3.9 ± 0.4 4.0 ± 0.4 4.4 ± 0.3# 4.5 ± 0.3# P = 0.055 P <0.0001 P = 0.715
Insulin iAUC (pmol/L/min−1) a
0–60 min 97.0 ± 59.4 102.4 ± 59.9 361.8 ± 226.4# 311.1 ± 215.5# P = 0.440 P <0.0001 P = 0.353
0–240 min 35.1 ± 20.0 30.81 ± 18.1 139.5 ± 90.2# 83.3 ± 54.6*# P = 0.047 P <0.0001 P = 0.379
GLP-1 iAUC (pmol/L/min−1) a
0–60 min 23.6 ± 7.4 7.3 ± 5.0* 19.4 ± 7.9 6.7 ± 4.0* P <0.0001 P = 0.217 P = 0.181
0–240 min 15.0 ± 4.3 4.7 ± 3.7* 11.8 ± 4.6# 5.2 ± 4.1* P = 0.001 P = 0.040 P = 0.011
GLP-1ACTIVE iAUC (pmol/L/min−1) a
0–60 min 3.8 ± 1.9 1.5 ± 1.1* 2.3 ± 1.4 1.1 ± 0.6* P <0.0001 P = 0.196 P = 0.217
0–240 min 2.0 ± 0.7 0.7 ± 0.4* 1.4 ± 0.7 0.8 ± 0.5* P <0.0001 P=0.426 P = 0.043
GLP-1ACTIVE/TOTAL iAUC (pmol/L × min−1) b
0–60 min 4.7 ± 2.6 2.5 ± 1.7* 2.4 ± 1.7# 1.9 ± 1.4 P = 0.009 P=0.021 P = 0.099
0–240 min 10.2 ± 6.4 5.2 ± 3.6* 7.1 ± 3.8 5.4 ± 4.7 P = 0.004 P = 0.386 P = 0.132
GIP iAUC (pmol/L/min−1) a
0–60 min 50.5 ± 19.0 51.8 ± 16.2 57.9 ± 23.0 53.9 ± 23.2 P = 0.650 P = 0.549 P = 0.383
0–240 min 36.5 ± 14.8 31.2 ± 13.7 43.3 ± 14.9 33.8 ± 13.7* P <0.0001 P = 0.382 P = 0.247
Acetaminophen AUC (mol/L/min-1) a
0-60min 65.1 ± 32.5 100.7 ± 31.1* 58.1 ± 19.7 90.0 ± 20.3* P <0.0001 P = 0.307 P = 0.787
0-240min 68.8 ± 14.9 77.5 ± 17.5 60.3 ± 13.1 67.2 ± 11.4 P = 0.029 P = 0.067 P = 0.793

Data presented as means ± SD.

a

Variables are presented as time-averaged during the early (0 -60 min) and total (0–240 min) postprandial period.

b

The iAUC for GLP-1ACTIVE/TOTAL is presented as the as the sum of iAUC over time (i.e., 60 or 240 min) and is thus, not time-averaged.

All data were analysed by a two-way mixed ANOVA. Between and within group differences were analysed if there were any significant main or interaction effects reported from the ANOVA.

*Denotes a within-group treatment effect (WP vs PLA).

#Denotes a between-group effect (lean vs centrally obese).

Bold values indicate statistical significance from the two-way mixed ANOVA.