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. 2021 Jun 18;11:648988. doi: 10.3389/fcimb.2021.648988

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Copyright © 2021 Wu, Zhang, Yang, Cui, Zhang, Xiao and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of proteome analyses. (A) Principal component analysis (PCA) of unstimulated monocytes (M) and monocytes stimulated with heat-killed C. albicans for 12 h (Y-12 h) and 24 h (Y-24 h) (n = 5). (B) Proteins differentially expressed in monocytes after 12 h and 24 h stimulation by heat-killed C. albicans versus M group were displayed in Venn diagrams. Bar graph shows the number of up- (red) and down-regulated (blue) proteins. (C, D) Hierarchical clustering analysis of differential proteins between the Y-12 h or Y-24 h and M group with a P < 0.05 (Student’s t-test). Normalized abundances of proteins were logarithmic transformed. (E, F) Pathway analysis of the differentially expressed proteins in monocytes stimulated by heat-killed C. albicans.