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. 2021 Jun 18;11:648988. doi: 10.3389/fcimb.2021.648988

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Copyright © 2021 Wu, Zhang, Yang, Cui, Zhang, Xiao and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The GLUT3-expression in patients with C. albicans BSI was preliminarily confirmed in monocytes. PBMCs were isolated from patients (n = 9) and healthy controls (n = 10), and then CD3^-CD14⁺GLUT3⁺ monocytes were separated by flow cytometer and compared using the non-parametric Mann-Whitney test (P < 0.0001). Representative flow cytometry dot plot (A) and summary data are shown (B). GLUT3 knockdown by siRNA significantly reduced production of IL-1β in the THP-1 cells. (C) The GLUT3 mRNA expression achieved by transfection of si-GLUT3 or negative control to THP-1 cells (n = 3). (D–F) Comparison of the secretion of IL-1β, IL-6, and TNF-α in THP-1 cells stimulated by C. albicans for 24 h (n = 4). ****P < 0.0001; **P < 0.01; *P < 0.05.