FIGURE 1.

TET1 is upregulated in hepatoblast‐like HCC. A, TET1 expression among hESCs, somatic tissues, and HCCs in expression microarray (U133 plus 2.0, Affymetrix). TET1: gene name, CXXC6; probe name, 228906_at. HCC, hepatocellular carcinoma; hESC, human embryonic stem cell; LC, liver cirrhosis (corresponding noncancerous liver); NL, normal liver. B, TET1 expression among 12 types of cancer in RNA‐seq data of TCGA project. BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; GBM, glioblastoma multiform; HCC, hepatocellular carcinoma; HNSC, head, and neck squamous cell carcinoma; KIRC, kidney renal clear cell carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; N, nontumor; OVCA, ovarian serous cystadenocarcinoma; READ, rectal adenocarcinoma; T, tumor; TCGA, The Cancer Genome Atlas; UCEC, uterine corpus endometrial carcinoma. The black dot represents the TET1 expression level (RSEM) of each case. Red line represents the median ± quartile. C, TET1 expression among clinical liver samples in expression microarray. Each dot represents the GeneChip score of TET1 (228906_at). Red line represents the median ± quartile. P‐values were measured using the Mann‐Whitney U‐test in (B) and (C). *P < .05; **P < .01; ***P < .001. D, Heatmap of the expression profiles using the probes which are highly correlated or inversely correlated with TET1 expression among clinical liver samples. E and F, Enrichment plot showing the enrichment score for the gene sets upregulated ^© and downregulated (F) in TET1 ^high HCCs