FIGURE 2.

Ablation of HSP47 enhances the sensitivity of pancreatic cancer cells to gemcitabine. A, Expression of HSP47 protein in HSP47 knockout (KO) PDAC cells (PANC1 cells and MIA‐PaCa2 cells). B, In vitro proliferation of HSP47 KO PDAC cells. C, Viability of HSP47 KO PDAC cells after treatment with gemcitabine. D, IC₅₀ values of HSP47 KO PDAC cells after treatment with gemcitabine at each indicated concentration. E, Expression of HSP47 protein in HSP47 KO PDAC cells expressing HSP47‐Myc. F, Viability of HSP47 KO PDAC cells expressing HSP47‐Myc after treatment with gemcitabine. G, IC₅₀ values of HSP47 KO PDAC cells expressing HSP47‐Myc after treatment with gemcitabine at each indicated concentration. *, P < .05