Table 2.

Enrichment of tracer within the main brain regions

Anatomical region	Group	0–0.5 h					0.5–3 h					3–7 h					∼ 24 h					∼ 48 h
		Mean	±	SE	P		Mean	±	SE	P		Mean	±	SE	P		Mean	±	SE	P		Mean	±	SE	P
Frontal cortex (GM)	IIH	2	±	7	ns		35	±	8	0.047		99	±	7	ns		97	±	8	0.033		50	±	8	ns
	REF	3	±	7			17	±	7			86	±	7			78	±	8			33	±	8
Frontal cortex (WM)	IIH	0	±	2	ns		0	±	2	ns		8	±	2	ns		31	±	2	0.004		24	±	2	0.001
	REF	–1	±	2			–1	±	2			4	±	2			25	±	2			17	±	2
Temporal cortex (GM)	IIH	3	±	8	ns		44	±	8	0.002		104	±	8	0.014		85	±	8	0.006		44	±	8	0.047
	REF	1	±	8			19	±	8			84	±	8			62	±	8			26	±	8
Temporal cortex (WM)	IIH	0	±	2	ns		2	±	3	ns		12	±	2	0.031		35	±	2	<0.001		25	±	2	<0.001
	REF	–2	±	2			–2	±	2			7	±	2			27	±	2			16	±	2
Parietal cortex (GM)	IIH	0	±	6	ns		12	±	6	ns		43	±	5	ns		59	±	6	ns		37	±	6	ns
	REF	2	±	5			10	±	5			54	±	5			62	±	6			29	±	6
Parietal cortex (WM)	IIH	–1	±	2	ns		0	±	2	ns		3	±	1	ns		18	±	2	ns		17	±	2	ns
	REF	–1	±	1			–1	±	1			3	±	1			20	±	2			14	±	2
Occipital cortex (GM)	IIH	0	±	6	ns		13	±	6	ns		40	±	6	ns		50	±	6	ns		30	±	6	ns
	REF	2	±	6			10	±	5			42	±	5			44	±	6			21	±	6
Occipital cortex (WM)	IIH	–1	±	2	ns		1	±	2	ns		5	±	2	ns		20	±	2	ns		16	±	2	ns
	REF	–1	±	2			–1	±	2			4	±	2			18	±	2			12	±	2
Cingulate cortex (GM)	IIH	3	±	10	ns		57	±	10	0.015		126	±	10	ns		89	±	10	0.054		41	±	10	ns
	REF	6	±	10			29	±	10			110	±	10			66	±	10			26	±	10
Cingulate cortex (WM)	IIH	0	±	1	ns		1	±	1	ns		7	±	1	ns		24	±	1	0.001		16	±	1	0.002
	REF	–1	±	1			0	±	1			4	±	1			18	±	1			10	±	1
Corpus callosum	IIH	1	±	2	ns		7	±	2	ns		20	±	2	ns		22	±	2	0.018		11	±	2	0.030
	REF	–1	±	2			3	±	2			16	±	2			15	±	2			5	±	2

GM = grey matter and WM = white matter. Data presented as percentage change in normalized T1 signal units over time. P: P-value (mixed model analysis) and ns = non-significant differences between groups.