TABLE 2.
ICP and CPP Burden Comparisons Between HTS and Mannitol Groups in 1:1 Matched Group
| HTS (n = 25) | Mannitol (n = 25) | ||||
|---|---|---|---|---|---|
| Mean ± SD | Med (IQR) | Mean ± SD | Med (IQR) | P-value | |
| ICP monitoring duration (days) | 6.4 ± 2.7 | 5 (4-9) | 7.7 ± 2.7 | 9 (7-10) | .09 |
| No. of days with ICPhigh + CPPlow | 0.6 ± 0.8 | 0 (0-1) | 2.4 ± 2.3 | 2 (0-4) | <.01* |
| % days with ICPhigh + CPPlow | 8.8 ± 10.6 | 0 (0-20) | 28.1 ± 26.9 | 22.2 (0-40) | <.01* |
| Total hours with ICPhigh + CPPlow | 11.12 ± 14.11 | 7 (1-18) | 30.56 ± 31.89 | 18 (10-44) | .01* |
| No. of days with CPPlow | 2.0 ± 1.7 | 1 (1-3) | 3.6 ± 2.8 | 3 (2-5) | .03* |
| % of days with CPPlow | 32.8 ± 23.9 | 30 (20-42.9) | 48.6 ± 44.7 | 33.3 (20-80) | .11 |
| Total hours with CPPlow | 8.88 ± 11.89 | 6 (1-13) | 18.96 ± 21.89 | 11 (3-23) | .06 |
| Averaged daily duration of CPPlow (hours) | 1.5 ± 2.2 | 0.7 (0.3-1.9) | 2.8 ± 3.9 | 1.1 (0.4-3.5) | .20 |
HTS, hypertonic saline; SD, standard deviation; IQR, interquartile range; ICP, intracranial pressure; CPP, cerebral perfusion pressure. *p < .05.