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. 2021 Jun 18;12:699807. doi: 10.3389/fimmu.2021.699807

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Copyright © 2021 Li, Yang, Cai, Guo, Fang, Cui, Gou, Deng, Wang and Zuo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resistin signaling pathways in inflammation and immune regulation. Resistin binding to the TLR4, CAP1 receptors, GPCR, and unknown receptors activates several signaling pathways leading to the immune cell activation and migration, neutrophil dysfunction, pro-inflammatory cytokines and chemokines production, and NETs formation. The anti-LPS-induced inflammation mediated by resistin through TLR4 may be in two ways: ① Resistin competes with LPS/MD2 for binding to TLR4 and suppresses pro-inflammatory signaling (i. e., NF-κB) while promotes anti-inflammatory signaling (i.e., STAT3, TBK1); ② Resistin directly binds to LPS and neutralize its inflammatory (endotoxin) activity.