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. 2021 Jul 2;16(7):e0253611. doi: 10.1371/journal.pone.0253611

Table 1. Description of the 13,552 TOPMed participants included in the main pooled whole genome sequence association analysis of MEAN handgrip strength and the 8,408 UK Biobank participants used for replication.

TOPMED UKBB AAa
TOTAL EAa AAa Othera MEN WOMEN TOTAL
N (%) 13,552 (100) 10,263 (76) 3,145 (23) 144 (1) 4,878 (36) 8,674 (64) 8,408 (100)
Age (years), mean (SD) 69 (14) 71 (11) 60 (18) 76 (6) 68 (14) 69 (14) 52 (8)
Height (cm), mean (SD) 165 (9.4) 165 (9.5) 166 (9.3) 158 (6.5) 174 (6.9) 160 (6.5) 168 (9)
BMI (kg/m2), mean (SD) 28.4 (5.8) 27.7 (5.2) 30.9 (7.0) 27.6 (5.3) 28.2 (4.8) 28.6 (6.3) 29.3 (5.4)
Handgrip strength (kg), mean (SD) 29.4 (11.2) 28.9 (10.9) 31.6 (11.9) 21.4 (7.2) 40.1 (9.9) 23.5 (6.5) 34.0 (11.7)

Mean covariates were calculated across all exams for which handgrip strength was available for the MEAN analysis.

aEA: White/European-American; AA: Black/African-American/African-ancestry; Other: Hispanic or Latino (N = 107), Asian or Pacific-Islander (N = 17), American-Indian or Alaskan-Native (N = 8), or other (N = 12).

b We identified UKBB African-ancestry participants using the following six self-reported ancestries: "Caribbean", "African", "Black or Black British", "Any other Black background", "White and Black African" and "White and Black Caribbean".