Table 3. IHC expression of EMT-related markers vs. histopathologic grades.
| WD | MD | PD | p-value | |
|---|---|---|---|---|
| E-cadherin | 0.122 | |||
| +1 | 0 (0.00) | 4 (3.10) | 1 (10.00) | |
| +2 | 0 (0.00) | 18 (13.95) | 4 (40.00) | |
| +3 | 3 (100.00) | 107 (82.95) | 5 (50.00) | |
| β-catenin | <0.001* | |||
| 0 | 2 (66.67) | 57 (44.53) | 5 (50.00) | |
| +1 | 0 (0.00) | 40 (31.25) | 2 (20.00) | |
| +2 | 1 (33.33) | 29 (22.66) | 0 (0.00) | |
| +3 | 0 (0.00) | 2 (1.56) | 3 (30.00) | |
| Claudin-1 | 0.001* | |||
| 0 | 0 (0.00) | 8 (6.20) | 4 (40.00) | |
| +1 | 3 (100.00) | 42 (32.56) | 4 (40.00) | |
| +2 | 0 (0.00) | 58 (44.96) | 2 (20.00) | |
| +3 | 0 (0.00) | 21 (16.28) | 0 (0.00) | |
| CD44 | 0.805 | |||
| 0 | 0 (0.00) | 10 (7.81) | 0 (0.00) | |
| +1 | 0 (0.00) | 42 (32.81) | 3 (30.00) | |
| +2 | 2 (66.67) | 55 (42.97) | 5 (50.00) | |
| +3 | 1 (33.33) | 21 (16.41) | 2 (20.00) | |
| N-cadherin | 0.009* | |||
| 0 | 3 (100.00) | 126 (97.67) | 9 (90.00) | |
| +1 | 0 (0.00) | 3 (2.33) | 0 (0.00) | |
| +2 | 0 (0.00) | 0 (0.00) | 1 (10.00) | |
| Fibronectin | 0.187 | |||
| 0 | 1 (33.33) | 9 (6.98) | 2 (20.00) | |
| +1 | 1 (33.33) | 75 (58.14) | 8 (80.00) | |
| +2 | 1 (33.33) | 42 (32.56) | 0 (0.00) | |
| +3 | 0 (0.00) | 3 (2.33) | 0 (0.00) | |
| Vimentin | 0.001* | |||
| negative | 3 (100.00) | 129 (100.00) | 9 (90.00) | |
| positive | 0 (0.00) | 0 (0.00) | 1 (10.00) | |
| S100A4 | 0.593 | |||
| 0 | 1 (33.33) | 35 (27.13) | 2 (20.00) | |
| +1 | 2 (67.67) | 57 (44.19) | 3 (30.00) | |
| +2 | 0 (0.00) | 22 (17.05) | 4 (40.00) | |
| +3 | 0 (0.00) | 15 (11.63) | 1 (10.00) |
WD: well differentiated, MD: moderately differentiated, PD: poorly differentiated.