Table 4. IHC expression of EMT-related markers vs. cancer stages classified into 0 to IV.
Cancer Stage | ||||||
---|---|---|---|---|---|---|
0 | Ⅰ | Ⅱ | Ⅲ | Ⅳ | p-value | |
E-cadherin | 0.201 | |||||
+1 | 0 (0.00) | 0 (0.00) | 0 (0.00) | 4 (7.27) | 1 (3.57) | |
+2 | 0 (0.00) | 3 (18.75) | 3 (7.32) | 8 (14.55) | 8 (28.57) | |
+3 | 2 (100.00) | 13 (81.25) | 38 (92.68) | 43 (78.18) | 19 (67.86) | |
β-catenin | 0.951 | |||||
0 | 1 (50.00) | 9 (56.25) | 17 (41.46) | 22 (40.74) | 15 (53.57) | |
+1 | 1 (50.00) | 5 (31.25) | 14 (34.15) | 15 (27.78) | 7 (25.00) | |
+2 | 0 (0.00) | 2 (12.50) | 8 (19.51) | 15 (27.78) | 5 (17.86) | |
+3 | 0 (0.00) | 0 (0.00) | 2 (4.88) | 2 (3.70) | 1 (3.57) | |
Claudin-1 | 0.293 | |||||
0 | 1 (50.00) | 1 (6.25) | 0 (0.00) | 7 (12.73) | 3 (10.71) | |
+1 | 1 (50.00) | 7 (43.75) | 15 (36.59) | 16 (29.09) | 10 (35.71) | |
+2 | 0 (0.00) | 7 (43.75) | 19 (46.34) | 25 (45.45) | 9 (32.14) | |
+3 | 0 (0.00) | 1 (6.25) | 7 (17.07) | 7 (12.73) | 6 (21.43) | |
CD44 | 0.646 | |||||
0 | 0 (0.00) | 2 (12.50) | 1 (2.44) | 5 (9.26) | 2 (7.14) | |
+1 | 1 (50.00) | 5 (31.25) | 10 (24.39) | 16 (29.63) | 13 (46.43) | |
+2 | 1 (50.00) | 5 (31.25) | 21 (51.22) | 24 (44.44) | 11 (39.29) | |
+3 | 0 (0.00) | 4 (25.00) | 9 (21.95) | 9 (16.67) | 2 (7.14) | |
N-cadherin | 0.350 | |||||
0 | 2 (100.00) | 16 (100.00) | 41 (100.00) | 52 (94.55) | 27 (96.43) | |
+1 | 0 (0.00) | 0 (0.00) | 0 (0.00) | 3 (5.45) | 0 (0.00) | |
+2 | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (3.57) | |
Fibronectin | 0.291 | |||||
0 | 1 (50.00) | 2 (12.50) | 2 (4.88) | 6 (10.91) | 1 (3.57) | |
+1 | 0 (0.00) | 11 (68.75) | 20 (48.78) | 33 (60.00) | 20 (71.43) | |
+2 | 1 (50.00) | 3 (18.75) | 18 (43.90) | 15 (27.27) | 6 (21.43) | |
+3 | 0 (0.00) | 0 (0.00) | 1 (2.44) | 1 (1.82) | 1 (3.57) | |
Vimentin | 0.393 | |||||
negative | 2 (100.00) | 16 (100.00) | 41 (100.00) | 55 (100.00) | 27 (96.43) | |
positive | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 1 (3.57) | |
S100A4 | 0.208 | |||||
0 | 1 (50.00) | 10 (62.50) | 7 (17.07) | 13 (23.64) | 7 (25.00) | |
+1 | 1 (50.00) | 3 (18.75) | 21 (51.22) | 27 (49.90) | 10 (35.71) | |
+2 | 0 (0.00) | 2 (12.50) | 8 (19.51) | 9 (16.36) | 7 (25.00) | |
+3 | 0 (0.00) | 1 (6.25) | 5 (12.20) | 6 (10.91) | 4 (14.29) |