Table 5. IHC expression of EMT-related markers vs. cancer stages classified into early stage (stages 0 to II) and advanced stage (stages III to IV).
| Cancer Stage | |||
|---|---|---|---|
| Early stage | Advanced stage | p-value | |
| Number | 57 | 83 | |
| E-cadherin | 0.041* | ||
| +1 | 0 (0.00) | 5 (6.02) | |
| +2 | 6 (10.17) | 16 (19.28) | |
| +3 | 53 (89.83) | 62 (74.70) | |
| β-catenin | 0.687 | ||
| 0 | 27 (45.76) | 37 (45.12) | |
| +1 | 20 (33.90) | 22 (26.83) | |
| +2 | 10 (16.95) | 20 (24.39) | |
| +3 | 2 (3.39) | 3 (3.66) | |
| Claudin-1 | 0.281 | ||
| 0 | 2 (3.39) | 10 (12.05) | |
| +1 | 23 (38.98) | 26 (31.33) | |
| +2 | 26 (44.07) | 34 (40.96) | |
| +3 | 8 (13.56) | 13 (15.66) | |
| CD44 | 0.411 | ||
| 0 | 3 (5.08) | 7 (8.54) | |
| +1 | 16 (27.12) | 29 (35.37) | |
| +2 | 27 (45.76) | 35 (42.68) | |
| +3 | 13 (22.03) | 11 (13.41) | |
| CD44 | 0.160 | ||
| 0 or +1 | 19 (32.20) | 36 (43.90) | |
| +2 or +3 | 40 (67.80) | 46 (56.10) | |
| N-cadherin | 0.227 | ||
| 0 | 59 (100.00) | 78 (95.12) | |
| +1 | 0 (0.00) | 3 (3.66) | |
| +2 | 0 (0.00) | 1 (1.22) | |
| Fibronectin | 0.481 | ||
| 0 | 5 (8.47) | 7 (8.43) | |
| +1 | 31 (52.54) | 53 (63.86) | |
| +2 | 22 (37.29) | 21 (25.30) | |
| +3 | 1 (1.69) | 2 (2.41) | |
| Vimentin | 0.397 | ||
| negative | 59 (100.00) | 82 (98.80) | |
| positive | 0 (0.00) | 1 (1.20) | |
| S100A4 | 0.855 | ||
| 0 | 18 (30.51) | 20 (24.10) | |
| +1 | 25 (42.37) | 37 (44.58) | |
| +2 | 10 (16.95) | 16 (19.28) | |
| +3 | 6 (10.17) | 10 (12.05) | |