Table 8. IHC expression of EMT-related markers vs. serum levels of CA 19–9.
Carbohydrate Antigen 19–9 | |||
---|---|---|---|
<37.00 | 37.00 + | p-value | |
Number | 86 | 22 | |
E-cadherin | 0.293 | ||
+1 | 3 (3.49) | 1 (4.55) | |
+2 | 9 (10.47) | 5 (22.73) | |
+3 | 74 (86.05) | 16 (72.73) | |
β-catenin | 0.01* | ||
0 | 30 (35.29) | 16 (72.73) | |
+1 | 27 (31.76) | 5 (22.73) | |
+2 | 23 (27.06) | 1 (4.55) | |
+3 | 5 (5.88) | 0 (0.00) | |
Claudin-1 | 0.148 | ||
0 | 5 (5.81) | 3 (13.64) | |
+1 | 32 (37.21) | 5 (22.73) | |
+2 | 31 (36.05) | 12 (54.55) | |
+3 | 18 (20.93) | 2 (9.09) | |
CD44 | 0.621 | ||
0 | 6 (7.06) | 0 (0.00) | |
+1 | 29 (34.12) | 8 (36.36) | |
+2 | 38 (44.71) | 10 (45.45) | |
+3 | 12 (14.12) | 4 (18.18) | |
CD44 | 0.682 | ||
0 or +1 | 35 (41.18) | 8 (36.36) | |
+2 or+3 | 50 (58.82) | 14 (63.64) | |
N-cadherin | 1.000 | ||
0 | 82 (96.47) | 22 (100.00) | |
+1 | 3 (3.53) | 0 (0.00) | |
Fibronectin | 0.141 | ||
0 | 9 (10.47) | 1 (4.55) | |
+1 | 45 (52.33) | 17 (77.27) | |
+2 | 30 (34.88) | 11 (31.43) | |
+3 | 2 (2.33) | 1 (4.55) | |
Vimentin | 1.000 | ||
negative | 86 (100.00) | 22 (100.00) | |
S100A4 | 0.917 | ||
0 | 24 (27.91) | 7 (31.82) | |
+1 | 35 (40.70) | 9 (40.91) | |
+2 | 17 (19.77) | 3 (13.64) | |
+3 | 10 (11.63) | 3 (13.64) |