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. 2021 Jul 2;16(7):e0254000. doi: 10.1371/journal.pone.0254000

Table 8. IHC expression of EMT-related markers vs. serum levels of CA 19–9.

Carbohydrate Antigen 19–9
<37.00 37.00 + p-value
Number 86 22
E-cadherin 0.293
+1 3 (3.49) 1 (4.55)
+2 9 (10.47) 5 (22.73)
+3 74 (86.05) 16 (72.73)
β-catenin 0.01*
0 30 (35.29) 16 (72.73)
+1 27 (31.76) 5 (22.73)
+2 23 (27.06) 1 (4.55)
+3 5 (5.88) 0 (0.00)
Claudin-1 0.148
0 5 (5.81) 3 (13.64)
+1 32 (37.21) 5 (22.73)
+2 31 (36.05) 12 (54.55)
+3 18 (20.93) 2 (9.09)
CD44 0.621
0 6 (7.06) 0 (0.00)
+1 29 (34.12) 8 (36.36)
+2 38 (44.71) 10 (45.45)
+3 12 (14.12) 4 (18.18)
CD44 0.682
0 or +1 35 (41.18) 8 (36.36)
+2 or+3 50 (58.82) 14 (63.64)
N-cadherin 1.000
0 82 (96.47) 22 (100.00)
+1 3 (3.53) 0 (0.00)
Fibronectin 0.141
0 9 (10.47) 1 (4.55)
+1 45 (52.33) 17 (77.27)
+2 30 (34.88) 11 (31.43)
+3 2 (2.33) 1 (4.55)
Vimentin 1.000
negative 86 (100.00) 22 (100.00)
S100A4 0.917
0 24 (27.91) 7 (31.82)
+1 35 (40.70) 9 (40.91)
+2 17 (19.77) 3 (13.64)
+3 10 (11.63) 3 (13.64)