Table 9. IHC expression of EMT-related markers vs. primary tumor locations.
Primary Tumor Location | ||||
---|---|---|---|---|
Right colon | Left colon | Rectum | p-value | |
E-cadherin | 0.464 | |||
+1 | 1 (2.44) | 0 (0.00) | 4 (6.25) | |
+2 | 8 (19.51) | 5 (13.51) | 9 (14.06) | |
+3 | 32 (78.05) | 32 (86.49) | 51 (79.69) | |
β-catenin | 0.017* | |||
0 | 29 (70.73) | 13 (35.14) | 22 (34.92) | |
+1 | 6 (14.63) | 13 (34.14) | 23 (36.51) | |
+2 | 5 (12.50) | 10 (27.03) | 15 (23.81) | |
+3 | 1 (2.44) | 1 (2.70) | 3 (4.76) | |
Claudin-1 | 0.603 | |||
0 | 4 (9.76) | 3 (8.11) | 5 (7.81) | |
+1 | 16 (39.02) | 16 (43.24) | 17 (26.56) | |
+2 | 17 (41.46) | 13 (35.14) | 30 (46.88) | |
+3 | 4 (9.76) | 5 (13.51) | 12 (18.75) | |
CD44 | 0.122 | |||
0 | 1 (2.44) | 3 (8.11) | 6 (9.52) | |
+1 | 10 (24.39) | 15 (40.54) | 20 (31.75) | |
+2 | 18 (43.90) | 17 (45.95) | 27 (42.86) | |
+3 | 12 (29.27) | 2 (5.41) | 10 (15.87) | |
CD44 | 0.126 | |||
0 or +1 | 11 (26.83) | 18 (48.65) | 26 (41.27) | |
+2 or +3 | 30 (73.17) | 19 (51.3) | 37 (58.73) |
|
N-cadherin | 0.187 | |||
0 | 40 (97.56) | 37 (100.00) | 61 (95.31) | |
+1 | 0 (0.00) | 0 (0.00) | 3 (4.69) | |
+2 | 1 (2.44) | 0 (0.00) | 0 (0.00) | |
Fibronectin | 0.026* | |||
0 | 8 (19.51) | 0 (0.00) | 4 (6.25) | |
+1 | 23 (56.10) | 23 (62.16) | 38 (59.38) | |
+2 | 10 (24.39) | 14 (37.84) | 19 (29.69) | |
+3 | 0 (0.00) | 0 (0.00) | 3 (4.69) | |
Vimentin | 0.289 | |||
negative | 40 (97.56) | 37 (100.00) | 64 (100.00) | |
positive | 1 (2.44) | 0 (0.00) | 0 (0.00) | |
S100A4 | 0.167 | |||
0 | 10 (24.39) | 8 (21.62) | 20 (31.25) | |
+1 | 24 (58.54) | 15 (40.54) | 23 (35.94) | |
+2 | 6 (14.63) | 9 (24.32) | 11 (17.19) | |
+3 | 1 (2.44) | 5 (13.51) | 10 (15.63) |