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. 2021 Jul 2;16(7):e0254000. doi: 10.1371/journal.pone.0254000

Table 9. IHC expression of EMT-related markers vs. primary tumor locations.

Primary Tumor Location
Right colon Left colon Rectum p-value
E-cadherin 0.464
+1 1 (2.44) 0 (0.00) 4 (6.25)
+2 8 (19.51) 5 (13.51) 9 (14.06)
+3 32 (78.05) 32 (86.49) 51 (79.69)
β-catenin 0.017*
0 29 (70.73) 13 (35.14) 22 (34.92)
+1 6 (14.63) 13 (34.14) 23 (36.51)
+2 5 (12.50) 10 (27.03) 15 (23.81)
+3 1 (2.44) 1 (2.70) 3 (4.76)
Claudin-1 0.603
0 4 (9.76) 3 (8.11) 5 (7.81)
+1 16 (39.02) 16 (43.24) 17 (26.56)
+2 17 (41.46) 13 (35.14) 30 (46.88)
+3 4 (9.76) 5 (13.51) 12 (18.75)
CD44 0.122
0 1 (2.44) 3 (8.11) 6 (9.52)
+1 10 (24.39) 15 (40.54) 20 (31.75)
+2 18 (43.90) 17 (45.95) 27 (42.86)
+3 12 (29.27) 2 (5.41) 10 (15.87)
CD44 0.126
0 or +1 11 (26.83) 18 (48.65) 26 (41.27)
+2 or +3 30 (73.17) 19 (51.3) 37 (58.73)
N-cadherin 0.187
0 40 (97.56) 37 (100.00) 61 (95.31)
+1 0 (0.00) 0 (0.00) 3 (4.69)
+2 1 (2.44) 0 (0.00) 0 (0.00)
Fibronectin 0.026*
0 8 (19.51) 0 (0.00) 4 (6.25)
+1 23 (56.10) 23 (62.16) 38 (59.38)
+2 10 (24.39) 14 (37.84) 19 (29.69)
+3 0 (0.00) 0 (0.00) 3 (4.69)
Vimentin 0.289
negative 40 (97.56) 37 (100.00) 64 (100.00)
positive 1 (2.44) 0 (0.00) 0 (0.00)
S100A4 0.167
0 10 (24.39) 8 (21.62) 20 (31.25)
+1 24 (58.54) 15 (40.54) 23 (35.94)
+2 6 (14.63) 9 (24.32) 11 (17.19)
+3 1 (2.44) 5 (13.51) 10 (15.63)