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. 2020 Jul 1;120(15):7592–7641. doi: 10.1021/acs.chemrev.0c00215

Figure 19.

Figure 19

(A) and (B) Wall-eyed stereo views of the structure of isoxicam overlaid with that of (S)-flurbiprofen bound in the COX-2 active site along with the residues that form the oxicam pocket. Isoxicam is shown in sienna, and the associated amino acid residues are in dark blue. (S)-Flurbiprofen is in tan, and the associated amino acids are in light blue. Note the large difference in the conformation of Leu-531 between the two structures. This rotation is necessary to provide access to the oxicam pocket. Note also the difference in the positions of Met-113, Val-116, and Leu-117 that results from the movement of helix D. From PDB 4M10 and 3PGH.