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. 2020 Jul 1;120(15):7592–7641. doi: 10.1021/acs.chemrev.0c00215

Figure 5.

Figure 5

(A) Wall-eyed stereo view of AA bound in the cyclooxygenase active site of COX-1 and the side chains that make up the proximal binding pocket (green), the central binding pocket (magenta), and the distal binding pocket (cyan). This view is similar to that used to depict most structures of fatty acids in complex with COX-1 or COX-2 throughout the review. (B) Wall-eyed stereo view of an overlay of the structures of four fatty acids in the active site of COX-1. Fatty acids and amino acid side chains are colored from lightest to darkest in the order of LA, DHLA, EPA, and AA. Notable is the minimal movement of active site residues to accommodate the structural differences among the various fatty acids. Monoscopic views of the individual structures are provided in Figure S1. From PDB 1DIY (A and B) and 1IGZ, 1FE2, and 1IGX (B only).