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. 2020 Jul 1;120(15):7592–7641. doi: 10.1021/acs.chemrev.0c00215

Figure 8.

Figure 8

Wall-eyed stereo view of AA bound to the active site of COX-1. (A) A pocket formed by Phe-381, Leu-384, Trp-387, Phe-518, and Met-522 provides space for formation of the endoperoxide ring. (B) Tyr-348, Phe-381, Typ-385, and Ser-530 surround carbon-15 of AA (green) dictating the orientation of oxygen addition at this site. AA is colored by element (with the exception of carbon-15 in B), and its surface is shown as a mesh. Side chains of the residues indicated are displayed, and their surface is shown in solid tan. From PDB 1DIY.