Figure 1.

(A) Activity of APOBEC mutagenesis in samples from five cancer types. Samples enriched with APOBEC mutagenesis (empirical threshold on enrichment = 2.0) are highlighted in red. (B and C) Examples of the mutational density distribution over replication timing with positive and negative slopes for the ACA/TGT motif of TCGA-CV-6961–01A sample of the HNSC cancer and the TCT/AGA motif of TCGA-05–4422-01A sample of the LUAD cancer, respectively. (D) Representative cancer samples with the calculated slopes of the mutation density distribution over replication timing for all trinucleotide motifs with the substitution in the central nucleotide. Trinucleotides TCN are highlighted in red.